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Anthony 'Tony' James Pawson, OC OOnt CH FRS FRSC, was a British-born Canadian scientist whose research has revolutionized the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signaling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.
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