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Sewall Green Wright was an American geneticist known for his influential work on evolutionary theory and also for his work on path analysis. With R. A. Fisher and J.B.S. Haldane, he was a founder of theoretical population genetics. He is the discoverer of the inbreeding coefficient and of methods of computing it in pedigrees. He extended this work to populations, computing the amount of inbreeding of members of populations as a result of random genetic drift, and he and Fisher pioneered methods for computing the distribution of gene frequencies among populations as a result of the interaction of natural selection, mutation, migration and genetic drift. The work of Fisher, Wright, and Haldane on theoretical population genetics was a major step in the development of the modern evolutionary synthesis of genetics with evolution. Wright also made major contributions to mammalian genetics and biochemical genetics.
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