Signature Theatre Company was founded in 1991 by James Houghton.
Signature has presented entire seasons of the work of Edward Albee, Lee Blessing, Horton Foote, Maria Irene Fornes, Athol Fugard, John Guare, Bill Irwin, Adrienne Kennedy, Romulus Linney, Charles Mee, Arthur Miller, Sam Shepard, Paula Vogel, August Wilson, Lanford Wilson, and a season celebrating the historic Negro Ensemble Company.
In October 2008, Signature announced the creation of The Pershing Square Signature Center. Designed by Frank Gehry Architects, the Center comprises three theatres, two rehearsal studios, a café and bar, bookstore, and offices all on one level. In its new home, Signature continues its Residency One and Legacy Program. Signature also introduced Residency Five, a program that will feature early- and mid-career playwrights and guarantee them three full productions over the course of a five-year residency.
Signature, its productions and its resident writers have been recognized with a Pulitzer Prize, eleven Lucille Lortel Awards, fifteen Obie Awards, five Drama Desk Awards, and twenty-two AUDELCO Awards. The National Theatre Conference recognized the company as the 2003 Outstanding National Theatre of the Year.